I – VIII Calmodulin – That changed the course of history and the correct concept of calcium

I. What is Osteoporosis and Osteosclerosis?

Definition of Osteoporosis

Osteoporosis happens when the lattice-like bony tissues in trabecular bones (spongy bones) start thinning due to certain factors, resulting in the widening of the gaps between bone tissues. In another word, the reduction of bone density, thereby leading to what is known as osteoporosis.








What is  Osteosclerosis?

An imbalance in the metabolism of calcium ions results in a high concentration of bone minerals in cortical bones, which leads to a tendency towards excessive calcification of the bones. Clinically, this is associated with such symptoms as aches, cramps and etc.

II.  Symptoms of osteoporosis


Loss of height


Bone fractures


III. Treatments for osteoporosis

1. Calcium supplements + Vitamin D3

2. Estrogen + progesterone

3. Calcitonin

4. Biphosphonate

5. A new domain in osteoporosis treatment: calmodulin

The correct concept

Without CBP (calcium-binding protein), calcium in the human body cannot exert its proper functions. According to the most current studies, the most important CBP in the human body is Calmodulin.




IV.  How to prevent osteoporosis?

Bone Density Test


Get regular bone density tests from a hospital or clinic. The test should be done once every four months.

Lifestyle Changes

A. Exercise daily for 15 minutes to 1 hour. Get a healthy dose of the sunlight to stimulate production of Vitamin D3, which helps the body absorbs calcium.

B. A moderate amount of weightlifting (or other resistance exercises) can stimulate the growth of bone tissues, thereby strengthening the bones.

C. Abstain from smoking and alcohol, reduce intake of caffeine and carbonated drinks.

V.   The calcium Deficiency Crisis

In his book entitled “Calcium & Health – The Fabulous Calcium”, Dr Takuo Fujita (PhD) of Kobe University, Japan, pointed out that:

  • Calcium is the flame of life

  • Our fight against calcium deficiency is a life-long battle

 According to the book, the risks of calcium deficiency include:

  1. Retarded growth in children (bone development and brain development).
  2. Ample amounts of calcium are needed during conception, to avoid those frightful pregnancy complications.
  3. Calcium deficiency can throw our immune system into disarray, result in hormone imbalance, and cause the retardation of nervous transmission.
  4. Calcium deficiency can cause cramps and weakness in the limbs, as well as shoulder ache and headache.
  5. Calcium is a crucial signal transmitter in completing the secretion of insulin. Therefore, calcium deficiency may also lead to diabetes.
  6. The root cause of most hypertension cases is calcium deficiency.
  7. Calcium deficiency can also result in arteriosclerosis and myocardial infarction.
  8. Calcium can help prevent liver diseases.
  9. Calcium deficiency can cause lithiasis.
  10. Calcium deficiency can result in cancers.
  11. Calcium deficiency can cause Alzheimer’s Disease and cataracts.
  12. Calcium deficiency is a known cause of osteoporosis.

VI.  Understanding the relationship between Ca2+ and CBP (calcium-binding proteins)

The crucial link between calcium ions and calcium-binding proteins (CBP) has already been medically proven. The most important CBP in the human body is Calmodulin (CaM). Calmodulin is a type of calcium-binding protein, whose role as a transmitter and inducer is crucial for calcium ion to exert its functions in most cells.

The calcium ions that exist at the cellular level are regulated by CaM. In an environment deprived of CaM, Ca2+ cannot effectively exert its functions. When  Ca2+ and CaM combine to form CaM-Ca+2 complex, it can stimulate enzyme activities, or alter the activity level of other structural proteins, or even play a vital role in signal transmission for hormones and nerve potential, which it accomplishes by altering the concentration of free calcium ions.

Furthermore, CaM is also a crucial part of the cellular scaffold, because it is the only protein that has the required appetency to link up many target sequences.

Conclusion: The efficiency of the molecular mechanisms and effects of Ca2+ in the human body depends on the presence of Calmodulin.

VII. Leading Researcher of Calcium Binding Protein

What is calmodulin

Professor Wang Kai Hua

World-renowned bioengineering researcher with a PhD in medicine

Specializes in the research of immunology, bioengineering and oncology

Has been involved in the above-mentioned studies for over 40 years

Recipient of nine State Technological Invention Awards (China)

The most state-of-the-art biochemical production procedures and facilities in the world.

A product of high-tech bioengineering

Single-cell culture  – formed by 148 amino acids — chelated with 4 calcium ions — protected by lecithin — able to pass through the stomach unaffected — arrives at the small intestine — forms ionic potential difference —  direct absorption

What is calmodulin 

VIII. What is CaM?

What is calmodulin1.   CaM = Calmodulin

2.   The Newton Medical Dictionary: a calcium-binding substance

3. PATS Medical Dictionary: Calmodulin, an intensifier for many enzymes; a protein that binds calcium ions


“What is CaM” – according to the Newton Medical Dictionary

What is calmodulin


Calmodulin [cytology]: a regulatory protein found in eukaryotic cells; forms unique coalescence with some enzymes, including enzymes involved in the functioning of cyclic nucleotides, muscle contraction, and nervous transmission, as well as certain kinds of phosphatase. Such coalescence relies on the presence of calcium ions. Such traits give it an appetency towards proteins, and the protein complex thus formed has a uniquely high level of effectiveness.

Definition of Calmodulin according to renowned medical dictionary 



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